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Geetha, K. M.
- Synthesis of 2-Imino-3-(5-Aryl-1, 3, 4-Thiadiazol-2-Yl)-5-Arylidene-1, 3-Thiazol-4-One as Potent CNS Depressant and Antimicrobial Agents
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry and Pharmacology, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bengaluru-560078, Karnataka State, IN
1 Department of Pharmaceutical Chemistry and Pharmacology, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bengaluru-560078, Karnataka State, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 3 (2010), Pagination: 698-702Abstract
2-Imino-3-(5-aryl-1, 3, 4-thiadiazolyl)-1,3-thiazol-4-one (E) have been synthesized from Arylaldehyde and Thiosemicarbazide. Condensation of the Iminothiazol-4-one with different substituted aromatic aldehyde and fused sodium acetate in glacial acetic acid to get 2-Imino-5-(4-substituted arylidene)-3-(5-aryl-1, 3, 4-thiadiazol-2-yl)-1,3- thiazol-4-one (F1-7). The structures of the synthesized compounds were conformed on the basis of spectral data. The compounds have been screened for their possible CNS depressant and anti microbial activities. Among the synthesized compounds F1, F2, F4 and F7 showed significant CNS depressant activity and compounds F1, F2, F4 and F6 showed moderate antimicrobial activity.Keywords
2-Imino-5-(4-Substituted Arylidene)-3-(5-Aryl-1, 3, 4-Thiadiazol-2-Yl)-1, 3-Thiazol-4-One, CNS Depressant, Antimicrobial Activity.- Synthesis of Some 1-[Bis-N, N-(2-Chloroethyl) Aminoacetyl]-3, 5-Disubstituted-1, 2-Pyrazolines as Possible Alkylating Anticancer Agents
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Authors
Affiliations
1 Dayanandasagar College of Pharmacy, Bangalore, Karnataka, IN
2 JSS College of Pharmacy, Ooty, Tamilnadu, IN
3 JKKMMRS College of Pharmacy, Kumarapalayam, Tamilnadu, IN
1 Dayanandasagar College of Pharmacy, Bangalore, Karnataka, IN
2 JSS College of Pharmacy, Ooty, Tamilnadu, IN
3 JKKMMRS College of Pharmacy, Kumarapalayam, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 496-499Abstract
A series of 1-[Bis-N, N-(2-Chloroethyl) aminoacetyl]-3,5-disubstituted-1,2 pyrazolines have been synthesized by the treatment of 1-[Bis-N, N-(2-hydroxyethyl) aminoacetyl]-3,5-disubstituted-1,2-pyrazolines with Phosphorous oxychloride, the starting compound pyrazoline was synthesized from various aldehydes and acetophenones. The synthesized compounds have been characterized by their analytical, IR, 1H-NMR and mass spectral data. The titled compounds were investigated for their possible anticancer activities by in vitro and in vivo methods. These compounds were found to exhibit a moderate anticancer activity when compared to cyclophosphamide employed as a reference drug for comparison.Keywords
Synthesis, Pyrazoline Derivatives, Anticancer Activity, Dalton’s Lymphoma Ascite (DLA) Cell Line.- Synthesis and Biological Evaluation of Some 2-(N-Substituted Hydrazino)-N-[4-(5-Methyl Benzoxazol-2-Yl)-Phenyl]-Acetamide
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Authors
Affiliations
1 Department of Pharamaceutical Chemistry, J.S.S. College of Pharmacy, Rocklands, Ooty, Tamil Nadu, IN
2 Department of Pharmaceutical Chemistry and Pharmacology, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore-560078, Karnataka State, IN
1 Department of Pharamaceutical Chemistry, J.S.S. College of Pharmacy, Rocklands, Ooty, Tamil Nadu, IN
2 Department of Pharmaceutical Chemistry and Pharmacology, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore-560078, Karnataka State, IN